Optical detection of COVID-19
The main advantage of this new optical technology over PCR lies in the speed of sample processing.
A new methodology – developed by Spanish researchers an der University of Seville – has obtained a sensitivity of 100 % and a specificity of 87.5 % in the detection of SARS-CoV-2 in nasopharyngeal exudate from symptomatic people. It has also been possible to detect the presence of SARS-CoV-2 in fresh saliva of asymptomatic people, as well as to detect, differentiate and quantify two types of synthetic viruses – lentiviruses and synthetic coronaviruses – in two biofluids. The main advantage of this new technology over PCR lies in the speed of sample processing and the ability of the optical system to simultaneously analyze a large number of samples.
The researchers warn that these results should still be viewed with caution, as they constitute a proof of concept, with relatively small numbers of cases, under partially controlled laboratory conditions. For this reason, they are currently working on validating this new methodology under generic conditions, including new variants of the virus and the effects of vaccines. This new methodology allows for the detection of viruses in liquid droplets and dry residues deposited on surfaces, through hyperspectral imaging and data processing based on advanced statistics and artificial intelligence.
It allows rapid processing of multiple samples simultaneously, without contact or reagents and with relatively simple equipment, usable by personnel with minimal training. This new technique uses standard optical equipment and has been developed so that it can be implemented in resource-constrained settings. The technique has been patented and the scientists are studying various options to set it up quickly and affordably.
The method and its implementation were designed by Emilio Gomez-Gonzalez, Principal Investigator at the ETSI Engineering School of the University of Seville, where he directs its Group of Interdisciplinary Physics (GFI), researcher at the Group of Applied Neuroscience of the Institute of Biomedicine of Seville (IBIS) and collaborator of the HUMAINT Project of the JRC. The C-CLEAN Project has been carried out by more than 30 researchers of 11 Spanish institutions, with a strong Andalusian component and European support. (Source: U. Seville)
Link: ETSI School of Engineering, Universidad de Sevilla, Sevilla, Spain
