‘Artificial retina’ could restore sight to the blind

“Worldwide, the number of people living with vision impairment is at least 2.2 billion. Our research aims to provide a biomedical solution to those experiencing blindness from retinitis pigmentosa and age-related macular degeneration (AMD), the second being one of the leading causes of blindness in the world,” said Dr Griffith. 

Dr Griffith hopes to ultimately apply this technology, a type of neural interface, to restore sensory function to those with spinal cord injuries, and to treat people with neurodegenerative diseases. A neural interface is a device that interacts with an individual’s nervous system to record or stimulate activity.

“Among other functions, neurons are the body’s signal conductors. A missing neuron link, which can be caused by, for example, a spinal cord injury, can cause severe problems. It can also be debilitating if neurons misfire – this can cause blindness and deafness, as well as diseases like Parkinson’s and epilepsy, for which there is no cure,” he said. Neural interfaces can bridge this neuronal divide, or, in the case of misfiring, re-program the neurons.

The device can be printed using the same, low-cost method as newspaper printing, with a high-speed roll to roll press. “Similar technologies are being intensively developed, though our device differs in that it is made of carbon – the same building block as human cells,” Dr Griffith said. “Other devices tend to be rigid and usually made of silicon or metal, which can present problems integrating with the human body that is soft and flexible. Our organic device is designed with this issue in mind.” 

Dr Griffith has been awarded an NHMRC Ideas grant to continue work on the project together with colleagues from the University of Sydney and neurobiologists from the University of Newcastle. It is intended that the device will be printed onto soft and flexible surfaces from water-based inks that contain nerve growth factors and then inserted into a patient’s retina by a surgeon.

Comparable technologies are attempting to replicate both the eye and the brain in an effort to restore sight. Yet, this method requires a more sophisticated approach. “Patients do get some vision back, which is definitely life-changing for those without sight. However, it’s not what you or I would think of as high-fidelity vision. Current state-of-the-art produces large blurry shapes in black and white,” Dr Griffith said. Another key difference is that the new device does not require any electricity – it is powered internally by light from the outside world. 

“If successful, our device will help us progress towards solving one of the great scientific challenges of the 21st  century; communicating with the human body’s sensory network. We hope to achieve this using nothing but light, which opens up some really exciting prospects for the future of bioelectronic technology.” (Source: Australian Centre for Microscopy & Microanalysis, University of Sydney)