02.02.2024 • NewsSmartkameras

A faster, more efficient imaging system for nanoparticles

A new technique pushes back some of the limits of the infrared imaging of rare-earth doped nanoparticles.

Teams led by Jinyang Liang and Fiorenzo Vetrone from the Énergie Matériaux Télé­communications Research Centre at the Institut national de la recherche scientifique (INRS) have developed a new system for imaging nano­particles. It consists of a high-precision, short-wave infrared imaging technique capable of capturing the photoluminescence lifetimes of rare-earth doped nanoparticles in the micro- to millisecond range. This discovery paves the way for promising appli­cations, parti­cularly in the biomedical and information security fields.

Jinyang Liang, Miao Liu and Fiorenzo Vetrone from INRS in front of the...
Jinyang Liang, Miao Liu and Fiorenzo Vetrone from INRS in front of the SWIR-PLIMASC device. (Source: INRS)

Rare-earth elements are strategic metals that possess unique light-emitting properties that make them very attractive research tools in cutting-edge science. What’s more, the photo­luminescence lifetime of nanoparticles doped with these ions has the advantage of being minimally affected by external conditions. As a result, measuring it through imaging provides data from which accurate and highly reliable information can be derived. Although this field is seeing remarkable progress, existing optical systems for this type of measurement were less than ideal.

“Until now, existing optical systems have offered limited possi­bilities due to inefficient photon detection, limited imaging speed, and low sensi­tivity,” explains Jinyang Liang, a specialist in ultrafast imaging and biophotonics. To date, the most common technique for measuring the photo­luminescence lifetime of rare-earth doped nanoparticles has involved counting time-correlated single photons. “This method requires a large number of repeated excitations at the same location because the detector can only process a limited number of photons for each excitation,” says Miao Liu, a PhD student in energy and materials science. However, the long photoluminescence lifetimes of rare-earth doped nanoparticles in the infrared spectrum, from hundreds of microseconds to several milliseconds, restrict the excitation’s repetition rate. As a result, the pixel dwelling time needed to build the photo­luminescence intensity decay curve is much longer.

To overcome this challenge, Liang and Vetrone’s teams have combined streak optics with a high-sensitivity camera. The resulting device is called SWIR-PLIMASC – short-wave infrared photo­­luminescence lifetime imaging microscopy using an all-optical streak camera. It vastly improves mapping of the optical properties of short-wave infrared photo­­luminescence lifetimes. It is the first high-sensi­tivity, high-speed SWIR imaging system in the optics field. “It has several advantages,” says Miao Liu. “For instance, it responds to a wide spectral range, from 900 to 1700 nano­meters, allowing photo­­luminescence to be detected at different wavelengths and/or spectral bands.”

The PhD student adds that with the help of this device, photo­luminescence lifetimes in the infrared spectrum, from microseconds to milliseconds, can be directly captured in one snapshot with a 1D imaging speed that can be tuned from 10.3 to 138.9 kilohertz. Finally, the operation that allocates the temporal information of photoluminescence to different spatial positions ensures that the entire process of 1D photoluminescence intensity decay can be recorded in a single snapshot, without repeated excitation. “You save time, but still get high sensi­tivity,” sums up Miao Liu.

The work carried out as part of this research will have a very tangible impact. In the biomedical field, the advances made possible by SWIR-PLIMASC could be used to fight cancer, believes Fiorenzo Vetrone, whose expertise lies in nanomedicine. “As our system applies to the temperature-based photo­­luminescence lifetime imaging of rare-earth ions, we believe that the data obtained could, for example, help to detect cancer cells even earlier and more accurately. The metabolism of those cells raises the temperature of the surrounding tissues,” says Vetrone.

The innovative system can also be used to store information at enhanced security levels, more specifically to prevent documents and data from being falsified. Finally, in funda­mental science, these unprecedented results will allow scientists to synthesize rare-earth nanoparticles with even more interesting optical properties. (Source: INRS)

Reference: M. Liu et al.: Short-wave Infrared Photoluminescence Lifetime Mapping of Rare-Earth Doped Nanoparticles Using All-Optical Streak Imaging, Adv. Sc., online 6 January 2024; DOI: 10.1002/advs.202305284

Link: Laboratory of Applied Computational Imaging, Centre Énergie Matériaux Télécommunications, Institut National de la Recherche Scientifique, Université du Québec, Varennes, Canada

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