Olympus has announced that its FluoView FV1000 confocal laser scanning microscope (cLSM) and FV1000MPE Multiphoton ranges can now be fitted with the PicoQuant module for Fluorescence Lifetime Imaging (FLIM) and Fluorescence Correlation Spectroscopy (FCS). FLIM and FCS are advanced methods for measuring minute changes in fluorescence that occur in cells over very short periods of time. FLIM is often used to accurately determine factors such as: O2, H2O or Ca2+ concentration; intracellular signal transduction; as well as molecular structure and dynamics. FCS applications include: molecular association/dissociation; concentration (fL range); kinetic rate constants; as well as in vitro and in vivo intramolecular dynamics.